Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS). Open through NCRI.
Study Assessing the "Best of" Radiotherapy vs the "Best of" Surgery in Patients with Oropharyngeal Carcinoma (Best of). Open and recruiting through EORTC, SAKK, and NCRI UK.
Phase III Randomized Controlled Trial Comparing Alternative Regimens for Escalating Treatment of Intermediate and High-Risk Oropharyngeal Cancer. Open through NCRI, open at Irish CTG.
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA. Coordinated by NRG Oncology. Accrued 284 with participating sites from the HKNPC study group, Singapore, and Taiwanese sites.
International multicentre study seeking to quantify the extent of discordance between p16 and HPV in oropharyngeal cancer, and its prognostic implications
HNCIG-10/Harmonization of Endpoints
This is an international collaboration which is reviewing recent publications and clinical trials to evaluate differences in endpoints used to assess locoregionally advanced and recurrent/metastatic head and neck cancers, with the goal of improving the definition and harmonization of endpoints.
HNCIG-11/iENE Delphi Consensus
Working to develop international consensus recommendations on terminology, methodology, modalities, and classification systems for identifying radiographic extracapsular nodal extension.
HNCIG-12/pENE Delphi Consensus
Working to develop international consensus recommendations on terminology, methodology, and importance of various degrees of pathologic extracapsular nodal extension.
HNCIG-13/Multi-Site Collaboration on Extranodal Extension
Multi-site study of data from patients treated for head and neck cancer, to examine and correlate findings of pathologic and radiologic ENE and to assess the significance of iENE as a prognostic factor.
Androgen Deprivation Therapy in Advanced Salivary Gland Cancer.
Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer (Published)
Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC (De-ESCALaTE). Open through NCRI, Cancer Trials Ireland. (Published)
AF CRT +/- Nimorazole in HNSCC
Transoral Surgery Followed by Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer
Platinum-Cetuximab Combined With Docetaxel or 5FU in Patients With Recurrent/Metastatic HNSCC.